Lab Meeting Schedule

The Adams lab gathers once a week for an hour and a half, during which we dissect primary research articles in a journal club format, students present their recent experimental data to the group, and/or protocols for research techniques are discussed.

Spring 2020 Lab Meetings – Thursdays, 10:00am-11:30am (as of 4/2/2020)

Date Presenter Topic
1/29/20 Ken Update on Lab Projects & Strategy for Spring 2020
2/5/20 Ken Update on ASBMB & Grant projects
2/12/20 Ken Data Talk
2/19/20 Adam Munoz et al. (2018) Journal of Biological ChemistryThe serine protease HtrA1 contributes to the formation of an extracellular 25-kDa apolipoprotein E fragment that stimulates neuritogenesis
2/26/20 Gordo Eftekharzadeh et al. (2018) Neuron. Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer’s Disease
3/4/20 CANCELLED – Spring Break
4/2/20 Ken Wang et al. (2018) Nature MedicineGain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector
4/9/20 Adele Shi et al. (2017) NatureApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy
4/16/20 Michaela Rauch et al. (2020) NatureLRP1 is a master regulator of tau uptake and spread
4/23/20 TBD TBD
4/30/20 TBA TBD

Fall 2019 Lab Meetings – Wednesdays, 4:30pm-6:00pm

Date Presenter Topic
9/11/19 Ken Update on Lab Projects and Strategy for Fall 2019
9/18/19 Adele & Rob Data talk
9/25/19 Gordo Boija et al. (2018) Cell. Transcription factors activate genes through phase separation capacity of their activation domains
10/2/19 Adele, Rob, & Gordo Practice FISH talks
10/9/19 All Group discussion projects status and strategies for moving forward
10/16/19 Gordo, Michaela, Adam Data talk
10/23/19 Adele Shrinivas et al. (2019) Molecular Cell. Enhancer Features that Drive Formation of Transcriptional Condensates
10/30/19 CANCELLED N/A
11/13/19 All Project updates & ASBMB abstracts submission
11/20/19 Rob Kilic et al. (2019) EMBO Journal. Phase separation of 53BP1 determines liquid-like behavior of DNA repair compartments
11/27/19 CANCELLED N/A
12/4/19 Michaela Sevetson et al. (2000) Journal of Biological Chemistry. A Novel Activation Function for NAB Proteins in EGR-dependent Transcription of the Luteinizing Hormone beta Gene
12/11/19 Michaela Conclude presentation on Sevetson et al. (2000)

Spring 2019 Lab Meetings – Thursdays, 11:00am-12:30pm

Date Presenter Topic
1/24/19 Ken Review of current Adams lab projects
2/7/19 Ken Protocol review – Cell splitting
2/14/19 Ken Protocol review – Cell counting
2/21/19 Everyone Srinivasan et al. (2006) NAB2 represses transcription by interacting with the CHD4 subunit of the nucleosome remodeling and deacetylase (NuRD) complex. J Biol Chem. 281(22):15129-37.
Techniques review embedded within the journal club discussion.
3/14/19 No Meeting – Spring Break
3/21/19 Gordo Mullenbrock et al. (2011) Global expression analysis identified a preferentially NGF-induced transcriptional program regulated by sustained ERK and AP-1 protein activation during PC12 cell differentiation. J Biol Chem. 286(52):45131-45.
3/28/19 Adele Adams et al. (2017) Role for Egr1 in the Transcriptional Program Associated with Neuronal Differentiation of PC12 Cells. PLoS ONE. 12(1):e0170076.
4/4/19 Ken Discussion on fundamentals of Alzheimer Disease pathology
4/11/19 Rob DeVos et al. (2018) Synaptic Tau Seeding Precedes Tau Pathology in Human Alzheimer’s Disease Brain. Front Neurosci. 12:267.
4/18/19 Kelsey & Jenna Garcia-Gutierrez et al. (2011) The transcription factor Krox20 is an E3 ligase that sumoylates its Nab coregulators. EMBO Rep. 12(10):1018-23.
4/25/19 Sarina György et al. (2018) CRISPR/Cas9 Mediated Disruption of the Swedish APP Allele as a Therapeutic Approach for Early-Onset Alzheimer’s Disease. Mol Ther Nucl Acids. 11:429-40.
5/2/19 Adam Wegmann et al. (2018) Tau protein liquid–liquid phase separation can initiate tau aggregation. EMBO J. 37:e98049.