The Adams lab gathers once a week for an hour and a half, during which we dissect primary research articles in a journal club format, students present their recent experimental data to the group, and/or protocols for research techniques are discussed.
Fall 2019 Lab Meetings – Wednesdays, 4:30pm-6:00pm
|9/11/19||Ken||Update on Lab Projects and Strategy for Fall 2019|
|9/18/19||Adele & Rob||Data talk|
|9/25/19||Gordo||Boija et al. (2018) Cell. Transcription factors activate genes through phase separation capacity of their activation domains|
|10/2/19||Gordo, Michaela, & Adam||Data talk|
|10/9/19||Adele||Shrinivas et al. (2019) Molecular Cell. Enhancer Features that Drive Formation of Transcriptional Condensates|
|10/23/19||Rob||Kilic et al. (2019) EMBO Journal. Phase separation of 53BP1 determines liquid-like behavior of DNA repair compartments|
Spring 2019 Lab Meetings – Thursdays, 11:00am-12:30pm
|1/24/19||Ken||Review of current Adams lab projects|
|2/7/19||Ken||Protocol review – Cell splitting|
|2/14/19||Ken||Protocol review – Cell counting|
|2/21/19||Everyone||Srinivasan et al. (2006) NAB2 represses transcription by interacting with the CHD4 subunit of the nucleosome remodeling and deacetylase (NuRD) complex. J Biol Chem. 281(22):15129-37.
Techniques review embedded within the journal club discussion.
|3/14/19||No Meeting – Spring Break|
|3/21/19||Gordo||Mullenbrock et al. (2011) Global expression analysis identified a preferentially NGF-induced transcriptional program regulated by sustained ERK and AP-1 protein activation during PC12 cell differentiation. J Biol Chem. 286(52):45131-45.|
|3/28/19||Adele||Adams et al. (2017) Role for Egr1 in the Transcriptional Program Associated with Neuronal Differentiation of PC12 Cells. PLoS ONE. 12(1):e0170076.|
|4/4/19||Ken||Discussion on fundamentals of Alzheimer Disease pathology|
|4/11/19||Rob||DeVos et al. (2018) Synaptic Tau Seeding Precedes Tau Pathology in Human Alzheimer’s Disease Brain. Front Neurosci. 12:267.|
|4/18/19||Kelsey & Jenna||Garcia-Gutierrez et al. (2011) The transcription factor Krox20 is an E3 ligase that sumoylates its Nab coregulators. EMBO Rep. 12(10):1018-23.|
|4/25/19||Sarina||György et al. (2018) CRISPR/Cas9 Mediated Disruption of the Swedish APP Allele as a Therapeutic Approach for Early-Onset Alzheimer’s Disease. Mol Ther Nucl Acids. 11:429-40.|
|5/2/19||Adam||Wegmann et al. (2018) Tau protein liquid–liquid phase separation can initiate tau aggregation. EMBO J. 37:e98049.|